Hepatoprotective and nephroprotective effects of Tessaria integrifolia Ruiz and Pav. on diclofenac-induced toxicity in rats

Background and Aim: Tessaria integrifolia Ruiz Pav. (also known as “Pájaro bobo”) is for its medicinal properties, including antiulcer, antiasthmatic, leishmanicidal, antipyretic, antispasmodic, diuretic, anti-inflammatory, analgesic, hepatoprotective effects. Therefore, we aimed to evaluate nephroprotective effects using a rat model of diclofenac-induced toxicity. Materials Methods: We administered three different doses the methanolic extract T. (100, 200, 400 mg/kg/day orally) compared them with commercial medicine silymarin (100 mg/kg orally). The rats received extracts 5 days, on days 3 4, 1 h after receiving extracts, diclofenac was intraperitoneally at dose 50 mg/kg. animals were euthanized 48 last injection, blood samples obtained measure biochemical parameters related liver kidney function, such alanine aminotransferase (ALT), aspartate (AST), bilirubin, cholesterol, triglycerides, creatinine, urea. Kidney tissues preserved in 10% formaldehyde sent histopathological analysis. Results: results show that has These are verified by lower levels ALT, AST, urea, creatinine group, which exhibited elevated parameters. In addition, analysis showed groups did not display necrosis or infiltration, observed group. Conclusion: effects, highest protective activity mg/kg/day. Keywords: diclofenac, hepatoprotective, nephroprotective, integrifolia.